Time-Efficient LIF Sensors for Manufacturing Sector

The enhanced Light Induced Fluorescence (LIF) Sensor from Natoli has helped monitor fluorophore solutes through built-in fluorescent sensing in the solid state.

The sensor gives a good range, low detection limits and excellent sensitivity leading to enhanced product quality by minimizing process issues and product waste generally prevalent in the pharmaceutical sector with improved root-cause analysis, while manufacturing. Efficiency is improved by minimizing the time needed to manufacture while an in-line approach ensures security for the operator.

The sensor can precisely measure remaining active pharmaceutical ingredients in both water used for rinsing and directly on surfaces, the whole process being made possible because fluorescence is almost 1,000 times more sensitive than absorbance spectroscopy.

This field analysis offers approximate cleaning validation and gets rid of swabbing. It also makes the process time-efficient by not needing samples to be sent for the time consuming high performance liquid chromatography (HPLC) analysis. The sensor can be used in various pharmaceutical blenders, while its in-built accelerometer technology is able to calculate the X-Y axis rotation of a Bin Blender or the Y-Z rotation of a V-Blender. The self-contained compact design and complex mechanical and automation features create a tough device to be used in many production applications.