Innovation in CO2 Sensor Technology

insights from industryYavuz CelikProduct ManagerHamilton Bonaduz AGIn our latest interview, AZoSensors speaks with Yavuz Celik from Hamilton, a global leader in CO₂ sensor technology, about their mission, recent innovations and the importance of parameter (CO₂) in cell cultivations.

For readers who may be new to the company, can you briefly introduce Hamilton?

Founded in the late 1940s, Hamilton is the leading manufacturer of precision liquid handling and measuring devices. Hamilton process analytics is a global leader in sensor technology, renowned for its innovative solutions in the life sciences industry. With a rich history of pioneering advancements, Hamilton has consistently pushed the boundaries of what is possible in process sensor technology.

Our mission is to enhance the precision and efficiency of bioprocessing through cutting-edge sensor technologies. From dissolved oxygen sensors to CO₂ monitoring systems, Hamilton's products are designed to meet the evolving needs of our customers, ensuring optimal performance and reliability in various applications. Our commitment to excellence is reflected in our robust R&D efforts and our dedication to providing exceptional customer support.

Hamilton's overall portfolio. Image Credit: Hamilton Bonaduz AG

Hamilton has a long-standing reputation for innovation in sensor technology. Could you share some highlights from the company’s journey and how its technologies have evolved over time?

Hamilton's journey in sensor technology is marked by several key milestones. Over the years, we have introduced groundbreaking products such as the Optical DO and Dencytee Arc sensors, which have revolutionized the way dissolved oxygen and cell density are measured.

Our integrated transmitter technology has further enhanced the accuracy and reliability of our sensors. These innovations have positioned Hamilton as a leader in the industry, continually evolving to meet the changing demands of the life sciences sector.

What are some of the key breakthroughs that have positioned Hamilton as a leader in process sensor technology?

One of the key breakthroughs that has positioned Hamilton as a leader in process sensor technology is our integrated transmitter. This technology allows for seamless communication between sensors and control systems, ensuring precise and real-time monitoring of critical parameters. Additionally, our optical measurement technology offers significant advantages over traditional methods, such as reduced drift and less frequent calibration. 

Hamilton's Sensor Portfolio. Image Credit: Hamilton Bonaduz AG

Why is dissolved CO₂ such a critical parameter in cell cultivation and bioprocess control?

Dissolved CO₂ is a critical parameter in cell cultivation and bioprocess control because it directly impacts the efficiency and scalability of bioreactors. Different mixing efficiencies at various scales can lead to the accumulation of CO₂ at the bottom of a bioreactor, which can be detrimental to cell health. Monitoring and controlling CO₂ levels are essential to maintaining optimal conditions for cell growth and metabolic activity.

What advantages does Hamilton’s CO₂ sensor technology offer compared to traditional methods of CO₂ monitoring?

Hamilton's CO₂ sensor technology offers several advantages over traditional methods of CO₂ monitoring. Our optical measurement technology eliminates the need for electrolytes, resulting in less drift and reduced calibration requirements. This ensures more accurate and reliable CO₂ monitoring, which is crucial for maintaining consistent bioprocess conditions.

Can you explain how real-time CO₂ monitoring can impact the consistency, scalability, and quality of biologics production?

Real-time CO₂ monitoring can significantly impact the consistency, scalability, and quality of biologics production. By maintaining optimal CO₂ levels, pH fluctuations can be minimized, leading to predictable growth rates and metabolic activity. Advanced bioprocessing systems integrate CO₂ sensors with automated feedback loops, enabling real-time adjustments as production scales up. Continuous CO₂ monitoring ensures that different batches of biologics production follow the same environmental conditions, resulting in reproducible and high-quality outcomes.

Image Credit: Hamilton Bonaduz AG

With the increasing demand for precision and efficiency in biomanufacturing, how is Hamilton preparing for the future of the industry?

Hamilton is preparing for the future of the biomanufacturing industry by developing more precise sensors and providing application support to help interpret sensor data. We act like a consulting company, offering expertise to improve bioprocess efficiency. Our focus on precision and efficiency ensures that we are well-equipped to meet the growing demands of the industry.

Are there any current trends or challenges in sensor technology that Hamilton is particularly focused on addressing?

Hamilton is focused on addressing several current trends and challenges in sensor technology, particularly shifting from electrochemical to optical sensors, which offer greater accuracy and reliability. Additionally, we recognize the value of data and are leveraging AI to enhance sensor performance. Our commitment to clever maintenance and long-life cycles also contributes to environmental sustainability.

Finally, what’s next for Hamilton? Is there anything exciting on the horizon?

Exciting developments are on the horizon for Hamilton. We have something big approaching towards the end of the year, so stay tuned. In the meantime, we invite readers to explore our entire portfolio and discover the innovative solutions we offer.

About Yavuz

Yavuz studied Mechanical Engineering at ETH Zurich, specializing in control systems and nanotechnology. After co-founding a start-up focused on ultra-pure water analysis using optical methods, he joined Hamilton Process Analytics in 2019 and began working on the first Dencytee Arc prototype. Following the product’s launch in 2022, he transitioned into product management, where he now supports both cell density sensors and CO₂ sensors.

This information has been sourced, reviewed and adapted from materials provided by Hamilton Company.

For more information on this source, please visit Hamilton Company.