Unattended, representative sampling for a wide range of chemical reactions.
Some Reactions are Difficult to Sample Without Affecting Reaction Progression
It is almost impossible to reliably take representative samples of oxygen or moisture-sensitive reactions and reactions at very high pressure or sub-ambient temperatures. Extremely toxic reactions pose further challenges. The innovative patented EasySampler probe allows the capture and instant quenching of reactions to offer a sample representative of a reaction during sampling.
EasySampler - Automated Sampling System for Chemical Reactions
Video Credit: METTLER TOLEDO
Sample and Quench at Reaction Conditions
How Does it Work?
The EasySampler is submerged into a reaction, where it stays for the entire experiment period. The sample pocket moves out, and a sample is filled in. When the pocket withdraws, the sample is quenched instantly at reaction conditions. Then, the sample is diluted to a user-defined concentration and ready for offline examination.
How EasySampler Takes Samples
Video Credit: METTLER TOLEDO
Representative and Reproducible Samples
From Heterogeneous and Multiphase Reactions
Sampling reactions with precision is a tough task. Sampling is particularly hard for heterogeneous and multiphase reactions. The EasySampler samples from the same point in the reactor into a pocket of fixed volume containing solids.
Solids dissolve instantly with the quench and dilution steps, supplying dissolved samples to gain representative, reproducible, and correct analytical data.
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Automated and Unattended 24/7
Never Miss a Sample Again
Sampling lethal or long reactions or reactions for Design of Experiments (DoE) studies can be laborious and almost impossible, resulting in blind spots in the data. Thus, experiments are often needed to be repeated. The EasySampler samples the same way each time and can be configured for nonstop sampling operations 24/7 to offer data sets for full reaction understanding, thus enhancing productivity.
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Sample Preparation
For HPLC-Ready Concentrations
Following the quenching process, the liquid handling system dilutes the sample to a user-defined concentration and conveys it to a vial, delivering it ready for offline examination. These steps can be used for derivatization, thereby reducing sample preparation time and preventing human error.
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Eliminate User Safety Concerns
Related to Toxic and Hazardous Chemistries
The EasySampler makes the sampling process completely automatic, preventing the need for manual liquid handling. This decreases risks and enhances operator safety, particularly with:
- Hazardous reactions at very high temperatures
- Extremely toxic chemistry
- Other risky reaction conditions
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Faster and Improved Chemical Development
With Integrated Reactor Systems and EasySampler
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The plug-and-play combination of OptiMax, EasyMax Advanced, and RX-10 with EasySampler allows faster chemical development. Automated reactors regulate reaction parameters while performing experiments 24 hours a day.
Incorporating the EasySampler offers representative samples during the reaction and superior-quality HPLC data for comprehensive and accurate reaction profiles. The iControl software regulates the reactor system and EasySampler, and reports all experiment-related data in a single file.
These integrated instruments can be used by researchers to swiftly comprehend, innovate, and make informed decisions so that reactions can be enhanced in a shorter period.
Common Applications of the EasySampler
- Conversion
- Yield
- Reaction kinetics
- Impurity profiling
- By-product formation
- Air-sensitive reactions
- Design of experiment studies
- Moisture-sensitive reactions
- Reactions at elevated pressure
- Hazardous and toxic reactions
- Reactions at sub-ambient temperatures
- Homogeneous reactions
Image Credit: METTLER TOLEDO